"Zhan Mitrev" Clinic: Hemofiltration is a long-established and proven method

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Due to the large number of questions and speculations that have been imposed on the public, we would like to provide publicly available, medically sound facts related to this method. Read and draw your own conclusion:

Fact 1: The method is neither new nor experimental. It was first put into use in the USA by Burton in 1976. and in Germany in 1977. by Cramer and Göttingen. Info on the link: https://pubmed.ncbi.nlm.nih.gov/9573587/ . Continuous Reno-Renal Replacement Therapy (CRRT) encompasses several different types of filtration. Hemofiltration is one type of CRRT method. It has been used in intensive care units around the world for 20 years. More info: https://www.baxter.ca/healthcare-professionals/critical-care

Fact 2: Hemofiltration as a method is performed using a specific machine and special filters that are placed on it, in combination with sterile prepared solutions intended for this procedure. The blood full of poisons passes through the filter that traps the poisons, and the purified blood is returned to the body. Let's emphasize that this happens in a closed sterile system, inside the filter, where the machine only performs the mechanical movement of the blood in the lines of the system, without direct contact of the blood with the machine itself. Read more https://pubmed.ncbi.nlm.nih.gov/32438839/ and watch the video: https://www.youtube.com/watch?v=lS_Msy6mpik

With this method, the blood is purified from:

  • poisons and decay products (urea, creatinine) that occur in certain diseases that lead to compromising kidney function;
  • created poisons, inflammatory toxic substances (interleukin-6, cytokines, endotoxins) during viral and bacterial infections of the body;

Fact 3: COVID-19 is no ordinary viral infection! From a medical point of view, the background of this disease is an inflammatory-immune response primarily to the endothelium (inner lining) of blood vessels throughout the body, which results in the release of inflammatory-inflammatory markers such as: cytokines, interleukins and other endotoxins, i.e. . poisons in the blood, due to which the condition of the patients very often deteriorates rapidly, and some of them end fatally. More details: https://pubmed.ncbi.nlm.nih.gov/34528075/

Fact 4: The method is widely used in dealing with the consequences of COVID-19. The first country to use it is China. Their medical experiences have shown that mortality in seriously endangered patients has decreased by 30% in those treated with this method. Read the full study: https://pubmed.ncbi.nlm.nih.gov/32438839/

And already in 2022, there will be numerous sublimated results from the application of this method. Read more at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9066462/

Fact 5: There are official approvals for the use of hemofiltration with the Oxyris filter in the treatment of COVID-19 patients, both in the USA and in the EU. And that:

  1. 10.04.2020/XNUMX/XNUMX by the FDA (Federal Food and Drug Administration of the United States). Official document in my original can be viewed here: https://www.fda.gov/media/137268/download ; https://www.nsmedicaldevices.com/news/baxter-oxiris-covid-19/https://www.fda.gov/medical-devices/coronavirus-disease-2019-covid-19-emergency-use-authorizations-medical-devices/continuous-renal-replacement-therapy-and-hemodialysis-devices-euas

In the same month, the recommendations for the use of this method in the United States were prepared. Official document in original: https://www.uab.edu/medicine/obriencenter/images/AKI_COVID-19_Recommendations_Document_03.21.2020.pdf

  1. 08.06.2020 CRRT method (machines, lines and filters) with all its types (including hemofiltration) enters the official list of essential medical devices (MDs and IVDs nomenclature for COVID-19) created by the European Commission. See the list here: https://docslib.org/doc/3569223/list-of-covid-19-essential-medical-devices-mds-and-ivds

This is followed by recommendations for the use of the same method in COVID-19 patients issued by 3 relevant associations: the European Intensive Care Association, the British Association and the Renal Association. Here is the link to the original document:
https://ukkidney.org/sites/renal.org/files/Clinical%20Practice%20Guideline_RRT%20for%20Critically%20Unwell%20Adult%20Patients_FINAL.pdf

Fact 6: The use of the filter for this method has been approved in Macedonia in August 2020 by MALMED (the Macedonian Agency for Medicines and Medical Devices).

Jean Mitrev Clinical Hospital he has been using this blood purification method since 2008 in the treatment of infective endocarditis (bacterial infection of the heart valves) in patients who need surgery, patients with myocarditis (infectious inflammation of the heart muscle), sepsis and the need for cardiac surgery, resulting in a positive outcome for treated patients. Meanwhile, in patients suffering from COVID-19, it starts to be used from June 2020. The use of this method is done strictly according to the recommendations given in the instructions for use of the Ogziris filter. Read the recommendations for use at: https://www.nsmedicaldevices.com/news/baxter-oxiris-covid-19/

We believe that it is important for the general public to know all this in order to maintain the level of relevance and for the discussion to continue to take place in the professional circles and competent institutions with which we cooperate, instead of spilling over into the media and on the streets, where generate unfounded speculations that are far from the truth, and that compromise hemofiltration as an established method for treating severe and critically ill patients in intensive care units, applied worldwide.

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